BI128: Fibroin Acne Patches Made From Leftover Silk Cocoons.

Tomohito Tsuda Vareechiangmai School

MIIX24 | Beginner Innovator

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The objective of this study is to investigate the effectiveness of inhibiting the bacteria that cause acne using acne patches containing extracts of tannin from guava leaves. The researchers aim to utilize naturally discarded materials to create a valuable product capable of addressing acne-related issues. The project begins with the extraction of tannin from guava leaves, which are cleaned and dried before being boiled with distilled water. The resulting extract is then filtered and diluted to concentrations of 100%, 50%, 25%, and 12.5%. The effectiveness of these concentrations in inhibiting acne-causing bacteria is tested using Azithromycin, Roxithromycin, Vancomycin, and distilled water as controls. The findings indicate that the 100% tannin extract and Roxithromycin demonstrate the highest effectiveness in inhibiting the bacteria responsible for acne in both oxygenated and non-oxygenated conditions. Subsequently, the remaining silk cocoons are used to extract fibroin, which is divided into two parts. One part is used to create acne patches, while the other part is mixed with tannin extract in a 1:1 ratio and tested for its inhibitory effects on acne-causing bacteria using Roxithromycin as a control. The results show that Roxithromycin is the most effective in inhibiting bacterial growth in both conditions, and the fibroin acne patches mixed with tannin extract exhibit inhibitory effects close to those of Roxithromycin. Finally, the material properties of fibroin are tested, including swelling degree, degradation degree, and gel fraction. It is observed that fibroin has high flexibility and excellent water absorption. In conclusion, the fibroin acne patches mixed with tannin extract from guava leaves prove to be a promising product for addressing acne-related issues.